Welcome to our Downstream Processing Library.

This library contains citations for our publications in the field of downstream processing. Copyright restrictions preclude us from providing electronic copies for some entries, but you are welcome to download any linked files for your individual personal used. Entries are posted in reverse chronological order in each section. There is a lot of new material and we’ll be updating content regularly so feel free to visit as often as you like. If you need Acrobat Reader, you can download a free copy from http://www.adobe.com/.

If you wish to use any of these files in support of a report or publication, you can cite the web address in place of the journal. The addresses for even the earliest files have remained unchanged since they were first posted, so you can be confident that readers and editors will be able to find them.

Some files are password protected. The password is validated.

Articles
Purification of IgM Monoclonal Antibodies, 2008, P. Gagnon, F. Hensel, R. Richieri, BioPharm Inernational, March suppl., 26-35

A Mechanistic Model for Adsorption of Immunoglobulin on Hydroxyapatite, 2007, Paul Ng, Jie He, and Pete Gagnon, J. Chromatography A, 1142 (1) 13-28

Building process control into chromatographic purification of viruses, Part 2, Purification as a tool for enhancing process control, 2006, Denise Gavin, FDA/CBER, Pete Gagnon, Validated Biosystems, BioProcess International, 4(11) 28-34. This reprint was kindly provided by BioProcess International. You can access this and other articles on their website at <http://www.bioprocessintl.com>

Builiding process control into chromatographic purification of viruses, Part 1, Qualification of critical manufacturing components, 2006, Denise Gavin, FDA/CBER, Pete Gagnon, Validated Biosystems, BioProcess International, 4(10) 22-30. This reprint was kindly provided by BioProcess International. You can access this and other articles on their website at <http://www.bioprocessintl.com>

Monoliths seen to revitalize bioseparations, Pete Gagnon, Genetic Engineering News, 26(17) October 1, 2006. This reprint was kindly provided by Genetic Engineering News. You can access this and other articles on their website at <http://www.genengnews.com/>

The secrets of orthogonal process design, Pete Gagnon, July 2006, http://www.validated.com/revalbio/pdffiles/orthopd.pdf

P. Ng, A. Cohen, P. Gagnon, 2006, Monoclonal antibody purification with CHT, Genetic Engineering News, 26(14)

P. Gagnon, 2006, The quest for a generic IgG purification process, BioProcessing Journal, 5(1) 29-34

P. Gagnon, P. Ng, C. Aberrin, J. Zhen, J. He, H. Mekosh, L. Cummings, R. Richieri, S. Zaidi, 2006, A ceramic hydroxyapatite based purification platform: simultaneous removal of leached protein A, aggregates, DNA, and endotoxins, BioProcess International, 4(2) 50-60. This reprint was kindly provided by BioProcess International. You can access this and other articles on their website at <http://www.bioprocessintl.com>

P. Gagnon, P. Ng, 2005, New Opportunities for Managing DNA with ceramic hydroxyaptatite and ceramic fluorapatite, Bioprocess International, 3(7) 52-4

P. Gagnon, 2000, Hydrophobic interaction chromatography with a non-salt buffer system for improving process continuity..., http://www.validated.com/revalbio/pdffiles/nsbhicab.pdf

P. Gagnon, 1999, Fine-Tuning Selectivity on Ion Exchangers, http://www.validated.com/revalbio/pdffiles/ionslect.pdf

P. Gagnon, 1999, Controlling Metal Ion Contamination in Purification Process Development, http://www.validated.com/revalbio/pdffiles/metcntam.pdf

P. Gagnon, 1999, Chromatofocusing: Does it Really Stand Up as a Process Tool? http://www.validated.com/revalbio/pdffiles/chrfocus.pdf

P. Gagnon, 1999, Maximizing Product Recovery in Hydrophobic Interaction Chromatography, http://www.validated.com/revalbio/pdffiles/hicretrn.pdf

P. Gagnon, 1999, Affinity Chromatography: The Fine Print, http://www.validated.com/revalbio/pdffiles/affinity.pdf

P. Gagnon, 1999,  Minimizing Product Loss on Ultrafiltration Membranes, http://www.validated.com/revalbio/pdffiles/filter.pdf

P. Gagnon, 1998, Expand your processing options with Hydrophilic Interaction Chromatography, http://www.validated.com/revalbio/pdffiles/hilic.pdf

P. Gagnon, 1998, Inactivating Virus Without Inactivating Your Product, http://www.validated.com/revalbio/pdffiles/virex.pdf

P. Gagnon, 1998, An Enigma Unmasked: How Hydroxtapatite Works and How to Make it Work For You, http://www.validated.com/revalbio/pdffiles/hxyapt.pdf

P. Gagnon, 1998, Why Anion Exchange Chromatography Works So Well for Endotoxin Removal -- Sometimes, http://www.validated.com/revalbio/pdffiles/endotox.pdf

P. Gagnon, T. Mayes, and A. Danielsson, 1997, An adaptation of hydrophobic interaction chromatography for estimation of protein solubility optima, J. Pharm. Biomed. Anal., 16 587-92, http://www.validated.com/revalbio/pdffiles/protsol.pdf

P. Gagnon, 1997, Avoiding instrument-associated aberrations in purification scale-up and scale-down, BioPharm, 10(3) 42-45

P. Gagnon and E. Grund, 1996, Large scale process development for hydrophobic interaction chromatography, part 4: Controlling selectivity, BioPharm, 9(5) 54-64

P. Gagnon and E. Grund, 1996, Large scale process development for hydrophobic interaction chromatography, part 3: Factors affecting capacity determination, BioPharm, 9 (3) 34-39. This article received the Best of BioPharm Award in bioseparations and downstream processing for 1996

P. Gagnon, E. Grund, and T. Lindbäck, 1995, Large scale process development for hydrophobic interaction chromatography, part 2: Controlling process variation, BioPharm, 8 (4) 36-41 (simultaneous publication in LC-GC, 13 400-410)

P. Gagnon, E. Grund, and T. Lindbäck, 1995, Large scale process development for hydrophobic interaction chromatography, part 1: Gel selection and development of binding conditions, BioPharm, 8 (3) 21-27 (simultaneous publication in LC-GC, 13 318-328)

P. Gagnon, P. Cartier, J. Maikner, R. Eksteen, and M. Kraus, 1993, A systematic approach to the purification of monoclonal antibodies, LC-GC, 11 26-34