The only sustainable competitive advantage is the ability to learn faster. –Kim Clark

Welcome! Validated Biosystems is an international consulting firm that has been providing expert guidance in downstream processing since 1987. We provide a range of resources to help you develop robust downstream manufacturing procedures quickly and efficiently, including a free downstream processing library on this website. We invite you to use these resources as they serve you best.

Purification Tools for Monoclonal Antibodies

New Publications on Downstream Processing
Arakawa, T., Kita, Y., Ejima, D., Gagnon, P. (2008) Solvent modulation of column chromatography, Prot. Pept. Lett., 15 (6) 544-555

The Promise of Monolith-based Industrial Purification of Biomolecules, 3rd International Monolith Symposium, May 30- June 4, 2008, Portoroz, Slovenia

Bringing Downstream Productivity into Phase with Upstream Antibody Production, 3rd International Monolith Symposium, May 30- June 4, 2008, Portoroz, Slovenia

Phosphate-free Buffer Systems: A New Frontier for Apatite Chromatography, 4th International Conference on Hydroxypatite, Sonoma, CA May 5-7, 2008

Multiple Modes of Aggregate Removal by Hydroxyapatite, 4th International Conference on Hydroxypatite, Sonoma, CA May 5-7, 2008

Previous publications are posted in our Downstream Processing Library.

In Press
Monoclonal IgG Purification by Mixed Mode Chromatography, in Process Scale Purification of Antibodies, Uwe Gottschalk, Ed.

Improved Antibody Aggregate Removal by Hydroxyapatite Chromatography in the Presence of Polyethylene Glycol, Journal of Immunological Methods

Monoliths Emerge as Important Tools for Industrial Purification, Genetic Engineering News

The Emerging Generation of Chromatography Tools for Virus Purification, Bioprocess International

Upcoming conferences
New options for eliminating the downstream processing bottleneck with monolithic chromatography supports and high efficiency fluid handling systems, BioProcess International Conference and Exhibition, Anaheim, CA, Sept. 23-26

New Resources in Downstream Processing
Monoliths
A Universal System for Scouting Chromatography Media
Pre-mixed non-ampholyte buffers for high resolution pH gradients
Progressive Research Systems
If you have a new resource that you think people in downstream processing should know about, please contact us about posting a link or brief description here (free).

Professional Opportunities
Manufacturing Associate, Purification. Avid Bioservices, Tustin, CA

This website is provided as a free service of Validated Biosystems Inc. You are welcome to print materials for your individual personal use. Permission is also freely granted to duplicate brief passages for the purpose of entering them into search databases or for publishing reviews. Permission will normally be granted to individuals or corporations wishing to use graphics or text from this publication in their own documents, however we ask that you contact us in advance and cite our URL as the source. Unauthorized reproduction of these materials, in any medium, is strictly prohibited by US and International law.


Information provided on this site has been obtained from sources believed to be reliable, however while every effort has been made to ensure its accuracy, no responsibility for loss or injury to any person acting or refraining from action as a result of the information contained herein can be accepted by the publisher, authors, editors, or service providers.