The only sustainable competitive advantage is the ability to learn faster. –Kim Clark
Welcome! Validated Biosystems is an international consulting firm that has been providing expert guidance in downstream processing since 1987. We provide a range of resources to help you develop robust downstream manufacturing procedures quickly and efficiently, including a free downstream processing library on this website. We invite you to use these resources as they serve you best.
Purification Tools for Monoclonal Antibodies.
New Publications on Downstream Processing
Gagnon, P., Hensel, F., Lee, S., Zaidi, S., 2010, IgM Purification: The Fine Print, Oral presentation, 4th International Monolith Symposium, Portoroz, Slovenia, May 29 - June 2, 2010
Gagnon, P., Adsorptive Chromatography: The Influence of Stationary Phase Architecture, Oral presentation, 4th International Monolith Symposium, Portoroz, Slovenia, May 29 - June 2, 2010
Gagnon, P., Rodriquez, G., Zaidi, S., Preliminary Results Towards Development of a Simple Rapid Method for Dissociation and Fractionation of Heavy and Light Chain from Monoclonal IgG, Poster, 4th International Monolith Symposium, Portoroz, Slovenia, May 29 - June 2, 2010
Gagnon, P., 2010, Hydroxyapatite for Biomolecule Purification, Genetic Engineering News, 30(7) 28-31
Previous publications are posted in our Downstream Processing Library.
Upcoming Conference Presentations
Gagnon, P., Competitive Dissociation of Antibody:DNA Complexes by Hydroxyapatite, BioProcess International Conference and Exhibition, Providence, Rhode Island, September 20-24, 2010
Current Development Projects
A Platform Purification Process for Clincal Grade Fab
Resources in Downstream Processing
Monoliths
A Universal System for Scouting Chromatography Media
Pre-mixed non-ampholyte buffers for high resolution pH gradients
Progressive Research Systems
If you have a new resource that you think people in downstream processing should know about, please contact us about posting a link or brief description here (free).
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Validated Biosystems Resource Guide for Downstream Processing
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Our downstream processing library currently includes articles addressing hydrophobic interaction chromatography, cation exchange chromatography, anion exchange chromatography, chromatofocusing, hydroxyapatite chromatography, fluorapatite chromatography, immobilized metal affinity chromatography, size exclusion chromatography, hydrophilic interaction chromatography, bio-affinity chromatography, protein A affinity chromatography, differential solubility chromatography, endotoxin removal, endotoxin complexation with proteins, DNA removal, DNA complexation with proteins, virus purification, virus removal, virus inactivation, contaminant complexation with proteins, protein formulation, protein stabilization, protein solubility determination, influence of matrix structure on chromatographic performance, degradation of chromatography media, breakdown of chromatography media, validation of chromatography media, process validation, purification process validation, influence of gradient conditions on chromatographic performance, linear versus step gradients, determination of protein binding capacity, membrane filtration losses, protein conjugation, development of immunoconjugates, fluorescent conjugates, immunotoxin conjugation, PEG conjugation, formulation, validation of protein purification processes, validation of virus purification processes, orthogonal process design, orthogonal process development, mass transport in chromatography media, diffusion and convection in chromatography media, monolithic chromatography media, chromatography on monoliths, membrane chromatography media, biotech consultants, biotechnology consultants, process development consultants, purification process development consultants, purification consultants, consultants for development of protein purification methods, consultants for development of virus purification methods, technical consultants for evaluation of venture opportunities, media scouting, courses in downstream processing, antibody purification with hydroxyapatite, aggregate removal with hydroxyapatite, leached protein A removal with hydroxyapatite, virus removal with hydroxyapatite, aggregate removal with fluorapatite, antibody purification with fluorapatite, endotoxin removal with hydroxyapatite
